Post-doctoral fellow (100%)

Research position

Would you like to participate in the evolution of research on dementia, Alzheimer's disease and dementia prevention? Would you like to collaborate with renowned specialists in this field?

In order to strengthen its dynamic team, the Memory Centre of Professor Giovanni Frisoni (part of the Department of Rehabilitation and Geriatrics) is looking for a :

Post-doctoral fellow (100%)

motivated to join our laboratory and contribute to a project focused on developing a probiotic cocktail for the treatment and prevention of Alzheimer’s disease. This ambitious project is part of the broader vision of the Memory Center, which aims to establish effective strategies for preventing Alzheimer’s disease and cognitive disorders in general.

The project is structured around three complementary research areas. The first involves an in-depth analysis of data collected from a human cohort of over 1,000 participants at various stages of the disease (healthy, preclinical, prodromal, and demented). This dataset includes a wide range of omics information, such as shotgun sequencing of the gut microbiome, proteomics, metabolomics, and detailed clinical data. Based on these analyses, a promising probiotic cocktail shall be identified and tested on preclinical murine models. These studies are expected to culminate in an interventional clinical trial targeting the human population.

This project will be conducted in close collaboration with a multidisciplinary team comprising a bioinformatician, a postdoctoral researcher, and two technicians. It is integrated into the Memory Center at the Geneva University Hospitals (HUG), which brings together approximately 40 professionals, including physicians, postdoctoral researchers, nurses, neuropsychologists, data managers, and research assistants.

https://www.unige.ch/medecine/migrg/en/groupes-de-recherche/935frisoni

The main tasks of the position are

- Lead the team to achieve the ultimate goal of conducting a human clinical trial with a targeted probiotic cocktail in humans within three years;
- Analyze and interpret the existing data;
- Coordinate the collection of necessary data from human and murine models;
- Design and implement preclinical experiments as needed;
- Establish the production or procurement of bacterial strains, as necessary;
- Present results at national and international events/conferences;
- Write scientific publications;
- Prepare additional grant applications as needed.

Geneva

Switzerland

12-month contract under private funding, renewable.

Full-time

Salary

Clinical Microbiology, Public Health, Microbiology

The successful candidate must hold a Ph.D. with a specialization in research on the interaction between the microbiota and physiology, with proven experience in this field and strong clinical knowledge.

Advanced expertise in developing probiotics for human use is essential.

Experience in statistical analysis applied to omics and metagenomic data, particularly related to the microbiome, would be highly valued.

Advanced knowledge of the interaction between the microbiota, immune system, and metabolism will be considered an asset, as well as bacteriology skills.

A background in neurodegenerative diseases would also be advantageous.

Proficiency in English (minimum C1 level) is required.

The mission of the Memory Centre at Geneva University Hospitals (HUG) is to deliver state-of-the-art care to patients with cognitive complaints and to develop translational research projects.

It tackles multiple challenges posed by memory disorders by offering a diagnosis founded on the latest techniques, multidisciplinary care, and individualised therapies. Patients can integrate research projects and get access to the latest treatments. A psycho-educational approach allows patients to better manage their disease and offers psychological support to their loved ones.

No

Yes

Mr

Prof

Frisoni

Giovanni B.

Centre de la mémoire (Geneva University Hospitals)

Department of Readaptation and Geriatrics

Rue Gabrielle-Perret-Gentil 6

Geneva

1205

Switzerland

If you correspond to the above description, we would be pleased to receive your application (covering letter with the names of two referees who can attest to the quality of the applicant's academic record, curriculum vitae with list of publications, diplomas), which should be submitted online :

https://jobs.unige.ch/www/wd_portal.show_job?p_web_site_id=1&p_web_page_id=68326